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Research

In its 2007-2010 project, CNO defined 5 research axes: 3 resulting from the reorganisation of the 5 axes proposed when the Cancéropôle was set up in 2003, and 2 new axes resulting from the strategic discussions that have taken place since 2006.

CNO now wishes to develop a series of joint, flagship projects as part of its 2011-2014 programme. These projects will increase CNO's visibility on the national and even international stage.

From development and validation of prognostic and predictive biomarkers to therapeutic innovation

The first axis, "From development and validation of prognostic and predictive biomarkers to therapeutic innovation", is perfectly in line with CNO's strategy to translate early scientific discoveries into new ways of treating colorectal cancer and thoracic cancer.

2011 – 2014 programme : 2 flagship projects

  • "The genetic determinism of colorectal cancer and breast cancer"
  • "Mechanisms of resistance to antiEGFR drugs"


Onset and evolution of tumours in malignant blood disorders

The second axis, “Onset and evolution of tumours in malignant blood disorders”, benefits from the long-standing involvement of CNO's researchers in large national and international cooperative groups, and from leading-edge tools developed by CNO's genomics facility.

2011 – 2014 programme : 2 flagship projects :

  • "Deciphering the Genetic HEterogeneity of DIffuse large B-cell lymphoma in the rituximab era: a translational and exploratory GELA project" - GHEDI
  • "The role of targeted resequencing and miRNA profiling in the diagnosis and prognosis of acute myeloid leukaemia" - AML resequencing


Multimodality targeting in oncology, CIMULCAN programme

The third axis, “Multimodality targeting in oncology, CIMULCAN programme”, which follows on from the 2005 radiotherapy network, integrates robot-aided treatment and biological targeting.

2011 – 2014 programme : 1 flagship project :

  • "Moving targets in high-precision photon radiotherapy" - MOVE


Cancer and Neurosciences

The research potential in the four regions covered by CNO is primarily focused on cancer and the neurosciences. The Cancéropôle's management very quickly realised the strategic importance of bringing these two fields together, in order to develop innovative, synergy-driven research projects within the frame of a fourth research axis, “Cancer and Neurosciences”.

2011 – 2014 programme : 1 flagship project :

  • "Cancer and Cognitive Function"


Cancer, Individual and Society

Getting researchers in Social Sciences and Humanities (SSH) more involved was one of the objectives of the first cancer plan. Given the huge potential revealed in 2006 by an inventory of SSH research projects within CNO's geographic scope, it seemed important to introduce a fifth research axis focusing on SSH, “Cancer, Individual and Society”.

2011 – 2014 programme : 1 flagship project :

  • "Intervention study in the general population aimed at reducing social inequalities in participation in colorectal cancer screening" - PRADO study